Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
Identifieur interne : 000B68 ( Main/Exploration ); précédent : 000B67; suivant : 000B69Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
Auteurs : Sabina Cauci [Italie] ; Secondo Guaschino ; Domenico De Aloysio ; Silvia Driussi [Italie] ; Davide De Santo ; Paola Penacchioni ; Franco QuadrifoglioSource :
- Molecular Human Reproduction [ 1360-9947 ] ; 2003-01.
English descriptors
- KwdEn :
- Teeft :
- Bacterial vaginosis, Cauci, Chemokines, Cytokine, Eld, Eschenbach, Gynecol, Healthy controls, Healthy women, High concentrations, High levels, High neutrophil counts, High neutrophils, High number, High numbers, Hillier, Immune, Innate factors, Innate immunity, Leukocyte, Median, Median value, Microbial, Mucosal, Neutrophil, Neutrophil recruitment, Obstet, Percentile, Positive women, Quadrifoglio, Reprod, Subgroup, Such differences, Udine, Vaginal, Vaginal neutrophils, Vaginalis, Vaginosis.
Abstract
Vaginal innate immunity in response to microbial perturbation is still poorly understood and could be crucial for protection from adverse outcomes. We investigated the relationship between interleukin (IL)‐8, IL‐1β and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive. Concentrations of IL‐8 and IL‐1β were highly correlated with counts of neutrophils in vaginal fluid of the entire population examined (111 subjects). Vaginal IL‐1β concentrations were significantly higher (P < 0.001) in BV positive women. There was no significant difference in IL‐8 levels or number of neutrophils between healthy controls and BV positive women. None of the healthy controls with high neutrophil counts (≥75th percentile, 14 average count per field) had high concentrations of IL‐1β (≥75th percentile, 220 pg/ml), whereas 84% of BV positive women with high neutrophil counts had high IL‐1β concentrations (P < 0.001). On the contrary, no difference in the percentage of subjects with elevated concentrations of IL‐8 (≥75th percentile, 2842 pg/ml) was found between healthy and BV positive women with high numbers of neutrophils (55.5% of healthy versus 53% of BV positive women). Our findings show that BV causes a large increase in IL‐1β concentrations which is not paralleled by an increase in IL‐8 concentrations in vaginal fluid, suggesting that BV‐associated factors more specifically dampen IL‐8 rather than IL‐1β. The lack of an increase in IL‐8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV).
Url:
DOI: 10.1093/molehr/gag003
Affiliations:
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Hum. Reprod.</title><idno type="ISSN">1360-9947</idno><idno type="eISSN">1460-2407</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-01">2003-01</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="53">53</biblScope><biblScope unit="page" to="58">58</biblScope></imprint><idno type="ISSN">1360-9947</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1360-9947</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Key words: bacterial vaginosis/interleukin‐1β/interleukin‐8/mucosal innate immunity/vaginal leukocytes</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bacterial vaginosis</term><term>Cauci</term><term>Chemokines</term><term>Cytokine</term><term>Eld</term><term>Eschenbach</term><term>Gynecol</term><term>Healthy controls</term><term>Healthy women</term><term>High concentrations</term><term>High levels</term><term>High neutrophil counts</term><term>High neutrophils</term><term>High number</term><term>High numbers</term><term>Hillier</term><term>Immune</term><term>Innate factors</term><term>Innate immunity</term><term>Leukocyte</term><term>Median</term><term>Median value</term><term>Microbial</term><term>Mucosal</term><term>Neutrophil</term><term>Neutrophil recruitment</term><term>Obstet</term><term>Percentile</term><term>Positive women</term><term>Quadrifoglio</term><term>Reprod</term><term>Subgroup</term><term>Such differences</term><term>Udine</term><term>Vaginal</term><term>Vaginal neutrophils</term><term>Vaginalis</term><term>Vaginosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vaginal innate immunity in response to microbial perturbation is still poorly understood and could be crucial for protection from adverse outcomes. We investigated the relationship between interleukin (IL)‐8, IL‐1β and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive. Concentrations of IL‐8 and IL‐1β were highly correlated with counts of neutrophils in vaginal fluid of the entire population examined (111 subjects). Vaginal IL‐1β concentrations were significantly higher (P < 0.001) in BV positive women. There was no significant difference in IL‐8 levels or number of neutrophils between healthy controls and BV positive women. None of the healthy controls with high neutrophil counts (≥75th percentile, 14 average count per field) had high concentrations of IL‐1β (≥75th percentile, 220 pg/ml), whereas 84% of BV positive women with high neutrophil counts had high IL‐1β concentrations (P < 0.001). On the contrary, no difference in the percentage of subjects with elevated concentrations of IL‐8 (≥75th percentile, 2842 pg/ml) was found between healthy and BV positive women with high numbers of neutrophils (55.5% of healthy versus 53% of BV positive women). Our findings show that BV causes a large increase in IL‐1β concentrations which is not paralleled by an increase in IL‐8 concentrations in vaginal fluid, suggesting that BV‐associated factors more specifically dampen IL‐8 rather than IL‐1β. The lack of an increase in IL‐8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV).</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="De Aloysio, Domenico" sort="De Aloysio, Domenico" uniqKey="De Aloysio D" first="Domenico" last="De Aloysio">Domenico De Aloysio</name><name sortKey="De Santo, Davide" sort="De Santo, Davide" uniqKey="De Santo D" first="Davide" last="De Santo">Davide De Santo</name><name sortKey="Guaschino, Secondo" sort="Guaschino, Secondo" uniqKey="Guaschino S" first="Secondo" last="Guaschino">Secondo Guaschino</name><name sortKey="Penacchioni, Paola" sort="Penacchioni, Paola" uniqKey="Penacchioni P" first="Paola" last="Penacchioni">Paola Penacchioni</name><name sortKey="Quadrifoglio, Franco" sort="Quadrifoglio, Franco" uniqKey="Quadrifoglio F" first="Franco" last="Quadrifoglio">Franco Quadrifoglio</name></noCountry><country name="Italie"><noRegion><name sortKey="Cauci, Sabina" sort="Cauci, Sabina" uniqKey="Cauci S" first="Sabina" last="Cauci">Sabina Cauci</name></noRegion><name sortKey="Driussi, Silvia" sort="Driussi, Silvia" uniqKey="Driussi S" first="Silvia" last="Driussi">Silvia Driussi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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